Computational Psychiatry · Open Science

LimbicLab

Model how cannabis interacts with bipolar vulnerability across polygenic risk. Stochastic ODE engine, kindling model, and plain-language neuroscience — all in your browser.

LimbicLab uses a stress-diathesis framing: vulnerability is widely distributed across people, and sustained stress can increase the chance of mood-disorder expression.

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Polygenic Risk

Input your own GWAS loci or use preset risk profiles. Watch how genetic loading shifts the manic-episode threshold in real time.

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Cannabis Exposure

Adjust THC/CBD potency and use frequency. The ODE engine models dopamine, serotonin, and GABA dynamics with CB1 receptor kinetics.

Kindling Model

Each simulated episode lowers the threshold for the next — mirroring Post's electrophysiological kindling hypothesis.

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